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KMID : 1129720220390010008
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Korean Journal of Acupuncture
2022 Volume.39 No. 1 p.8 ~ p.15
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Effect of Kidney Tonification of Saam Acupuncture in Parkinson’s Disease Mouse Model
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Kim Seung-Tae
Lee Sang-Hyup
Kim Bo-Kyung
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Abstract
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Objectives : Saam acupuncture is one of the indigenous therapeutic modalities in traditional Korean medicine. In this study, the neuroprotective effect of Saam acupuncture of kidney tonification was investigated using 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-treated mice.
Methods : Twelve-week-old male C57BL/6 mice were intraperitoneally administered with 30 mg/kg of MPTP at 24-h intervals for 5 days and acupuncture stimulation at LU8, KI7, SP3 and KI3 was performed once a day for 12 days from the first MPTP injection. The pole test and the rotarod test were performed to evaluate motor function, and dopaminergic neuronal survival in the substantia nigra (SN) and striatum was evaluated using tyrosine-hydroxylase immunohistochemistry.
Results : MPTP administration caused behavioral impairment and dopaminergic neuronal death in the nigrostriatal pathway. Whereas the Saam acupuncture treatment alleviated the MPTP-induced motor dysfunction and dopaminergic neuronal death in the SN and striatum.
Conclusions : Saam acupuncture of kidney tonification can alleviate the MPTP-induced motor dysfunction and dopaminergic neuronal death in the nigrostriatal pathway, suggesting a possible role for acupuncture in the treatment of Parkinson’s disease.
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KEYWORD
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Saam acupuncture, acupoint, kidney meridian deficiency, Parkinson’s disease, 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)
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